NLRP3-IN-69

NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κB p65 and the formation of NLRP3 inflammasome. NLRP3-IN-69 inhibits LPS (HY-D1056) -induced overexpression of IL-1β, iNOS and COX-2, inhibits NO generation (IC50=5.66 μM), thereby exhibiting anti-inflammatory activity[1].

Product Specifications

CAS Number

[3027608-60-9]

UNSPSC

12352005

Target

COX; Interleukin Related; NF-κB; NO Synthase; NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation; NF-κB

Field of Research

Inflammation/Immunology

Smiles

COC1=C(OC)C(OC)=CC(/C=C/C(OC2=CC(C=CC([C@@H](C(O)=O)C)=C3)=C3C=C2)=O)=C1

Molecular Formula

C25H24O7

Molecular Weight

436.45

References & Citations

[1]Yu J, et al., Novel Cinnamic Acid Derivatives Containing Naproxen as NLRP3 Inhibitors: Synthesis and Evaluation of Their Biological Activity. Chem Biodivers. 2024 Dec 29:e202402700.