NDM-1 inhibitor-7
NDM-1 inhibitor-7 (Compound A8) is a NDM-1 inhibitor, with IC50 of 10.284 μM. NDM-1 inhibitor-7 restores the ability of MEM to penetrate the cell wall of gram-negative bacteria. NDM-1 inhibitor-7 effectively restores the antibacterial activity of MEM against NDM-1-positive Escherichia coli. NDM-1 inhibitor-7 demonstrates strong efficacy in both the Galleria mellonella infection model and murine peritonitis infection model[1].
Product Specifications
CAS Number
[26151-73-5]
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection; Inflammation/Immunology
Smiles
OC1=C(/C=N\NC(SC)=S)C=CC=C1
Molecular Formula
C9H10N2OS2
Molecular Weight
226.32
References & Citations
[1]Wang N, et al. Novel methyldithiocarbazate derivatives as NDM-1 inhibitors to combat multidrug-resistant bacterial infection with β-lactams. Bioorg Chem. 2025 Jan;154:108104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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