NDM-1 inhibitor-7

NDM-1 inhibitor-7 (Compound A8) is a NDM-1 inhibitor, with IC50 of 10.284 μM. NDM-1 inhibitor-7 restores the ability of MEM to penetrate the cell wall of gram-negative bacteria. NDM-1 inhibitor-7 effectively restores the antibacterial activity of MEM against NDM-1-positive Escherichia coli. NDM-1 inhibitor-7 demonstrates strong efficacy in both the Galleria mellonella infection model and murine peritonitis infection model[1].

Product Specifications

CAS Number

[26151-73-5]

UNSPSC

12352005

Target

Bacterial; Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection; Inflammation/Immunology

Smiles

OC1=C(/C=N\NC(SC)=S)C=CC=C1

Molecular Formula

C9H10N2OS2

Molecular Weight

226.32

References & Citations

[1]Wang N, et al. Novel methyldithiocarbazate derivatives as NDM-1 inhibitors to combat multidrug-resistant bacterial infection with β-lactams. Bioorg Chem. 2025 Jan;154:108104.