Antiproliferative agent-66

Antiproliferative agent-66 (Compound B3) is an antiproliferative agent that induces apoptosis and cell cycle arrest with IC50 values in the range of 2.03-3.6 µM against SH-SY5Y neuroblastoma, HT-29 colorectal adenocarcinoma, and fibroblast cells. Antiproliferative agent-66 is also a tubulin polymerization inhibitor with an IC50 of 0.79 µM[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=NC=CN1CC2=CSC(C3=CC4=CC=CC=C4C=C3)=N2

Molecular Formula

C18H15N3S

Molecular Weight

305.40

References & Citations

[1]Valipour M, et al. Design, synthesis, and structure-activity relationships of five-membered heterocyclic incorporated aryl (alkyl) azoles: From antiproliferative thiazoles to safer anticonvulsant oxadiazoles. Bioorg Chem. 2025 Feb;155:108117.