Antiproliferative agent-66
Antiproliferative agent-66 (Compound B3) is an antiproliferative agent that induces apoptosis and cell cycle arrest with IC50 values in the range of 2.03-3.6 µM against SH-SY5Y neuroblastoma, HT-29 colorectal adenocarcinoma, and fibroblast cells. Antiproliferative agent-66 is also a tubulin polymerization inhibitor with an IC50 of 0.79 µM[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=NC=CN1CC2=CSC(C3=CC4=CC=CC=C4C=C3)=N2
Molecular Formula
C18H15N3S
Molecular Weight
305.40
References & Citations
[1]Valipour M, et al. Design, synthesis, and structure-activity relationships of five-membered heterocyclic incorporated aryl (alkyl) azoles: From antiproliferative thiazoles to safer anticonvulsant oxadiazoles. Bioorg Chem. 2025 Feb;155:108117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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