Menin–KMT2A-IN-1
Menin–KMT2A-IN-1 (Compound 20) is the inhibitor for menin–KMT2A that binds to menin with an IC50 of 8 nM, and inhibits the interaction between menin and lysine methyltransferase 2A (KMT2A) . Menin–KMT2A-IN-1 inhibits hERG with an IC50 of 65 μM. Menin–KMT2A-IN-1 inhibits cell MV4-11 with an IC50 of 74 nM. Menin–KMT2A-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mouse with an orally bioavailability of 74%[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Potassium Channel
Related Pathways
Epigenetics; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=CC=C(OC2=NN=CN=C2N3CC4(CCN(CC5(C)CC5)CC4)C3)C(C(N6C7COCC6CC7)=O)=C1
Molecular Formula
C28H35FN6O3
Molecular Weight
522.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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