DS79932728
DS79932728 is an orally active inhibitor for G9a and GLP with IC50 of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF) . DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models[1].
Product Specifications
CAS Number
2757191-62-9
UNSPSC
12352005
Target
GLP Receptor; Histone Methyltransferase
Related Pathways
Epigenetics; GPCR/G Protein
Field of Research
Others
Smiles
NC1=NC2=CC(C3=CCN(C)CCC3)=C(OC)C=C2C14CCC4
Molecular Formula
C19H25N3O
Molecular Weight
311.42
References & Citations
[1]Katayama K, et al., Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease. ACS Med Chem Lett. 2020 Dec 28;12 (1) :121-128.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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