DS79932728

DS79932728 is an orally active inhibitor for G9a and GLP with IC50 of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF) . DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models[1].

Product Specifications

CAS Number

[2757191-62-9]

UNSPSC

12352005

Target

GLP Receptor; Histone Methyltransferase

Related Pathways

Epigenetics; GPCR/G Protein

Field of Research

Others

Smiles

NC1=NC2=CC(C3=CCN(C)CCC3)=C(OC)C=C2C14CCC4

Molecular Formula

C19H25N3O

Molecular Weight

311.42

References & Citations

[1]Katayama K, et al., Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease. ACS Med Chem Lett. 2020 Dec 28;12 (1) :121-128.