SMD-1087

SMD-1087 is a PROTAC that selectively targets SMARCA2 (DC50=8 nM, Dmax=89%) and SMARCA4 with a DC50 of 1 μM. SMD-1087 consists of the E3 ligase ligand (S, R, S) -AHPC-Me (blue part) (HY-112078), the target protein ligand SMI-1074 (red part) (HY-170817), and the PROTAC linker (1r,4r) -tert-Butyl 4- (bromomethyl) cyclohexanecarboxylate (black part) (HY-W890392) . Among them, its target protein ligand + Linker part corresponds to SMARCA2 Ligand-Linker Conjugate-1 (HY-170829) [1].

Product Specifications

CAS Number

[3033586-04-5]

UNSPSC

12352005

Target

PROTACs; SWI/SNF Complex

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

C[C@H](NC([C@@H]1C[C@H](CN1C([C@@H](NC([C@@H]2CC[C@H](CC2)CN3CCC(CC3)C4=CC(N5C6=C7C(Cl)=CC=C6)=C(C=C4)C8(CCCCC8)C5=NC7=O)=O)C(C)(C)C)=O)O)=O)C9=CC=C(C=C9)C%10=C(C)N=CS%10

Molecular Formula

C56H68ClN7O5S

Molecular Weight

986.70

References & Citations

[1]Leng L, et al. Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders. J Med Chem. 2025 Jan 23;68 (2) :1113-1133.