E3 Ligase Ligand-linker Conjugate 159

E3 Ligase Ligand-linker Conjugate 159 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 159 can be used for the synthesis of SMD-3236 (HY-170824), a PRAOTAC that targets the degradation of SMARCA2, exhibiting long-lasting antitumor activity in vivo[1].

Product Specifications

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C(N1[C@H](C(N[C@@H](CN2CCOCC2)C3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C1)[C@H](C(C)(C)C)N5N=NC([C@H](CC6)CC[C@@H]6COS(C)(=O)=O)=C5

Molecular Formula

C37H53N7O7S2

Molecular Weight

771.99

References & Citations

[1]Yang L, et al. Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers. J Med Chem. 2025 Jan 23;68 (2) :1155-1178.