SMARCA2 ligand-14
SMARCA2 ligand-14 is the ligand for SMARCA2 that can be used for synthesis of PROTAC degrader SMD-3236.
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SWI/SNF Complex
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C(N1[C@H](C(N[C@@H](CN2CCOCC2)C3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C1)[C@H](C(C)(C)C)N5N=NC(C)=C5
Molecular Formula
C30H41N7O4S
Molecular Weight
595.76
References & Citations
[1]Yang L, et al., Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers. J Med Chem. 2025 Jan 23;68 (2) :1155-1178.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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