PRC1-IN-1

PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex PRC1 (IC50=2.3 μM), targeting RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1 with IC50s of 2.8, 2.6, and 1.8 μM, respectively[1].

Product Specifications

CAS Number

[2396639-29-3]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Purity

97.30

Smiles

CC(C1=C(NC(C(O)=O)=C1C2=C(C=CC3=C2C=CN3)Cl)C4=CC(F)=CC5=C4C=CN5)C

Molecular Formula

C24H19ClFN3O2

Molecular Weight

435.88

References & Citations

[1]Yao Y, et al. Development of PRC1 Inhibitors Employing Fragment-Based Approach and NMR-Guided Optimization. J Med Chem. 2025 Jan 23;68 (2) :1382-1396.