PRC1-IN-1
PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex PRC1 (IC50=2.3 μM), targeting RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1 with IC50s of 2.8, 2.6, and 1.8 μM, respectively[1].
Product Specifications
CAS Number
[2396639-29-3]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Purity
97.30
Smiles
CC(C1=C(NC(C(O)=O)=C1C2=C(C=CC3=C2C=CN3)Cl)C4=CC(F)=CC5=C4C=CN5)C
Molecular Formula
C24H19ClFN3O2
Molecular Weight
435.88
References & Citations
[1]Yao Y, et al. Development of PRC1 Inhibitors Employing Fragment-Based Approach and NMR-Guided Optimization. J Med Chem. 2025 Jan 23;68 (2) :1382-1396.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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