VK13

VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) with a Ki value of 0.55 nM and SARS-CoV-2 3CLpro (3CL-PR) with a Ki value of 2.6 nM. VK13 exhibits anti-CoV-2 activity with an EC50 of 1.25 μM[1].

Product Specifications

UNSPSC

12352005

Target

Cathepsin; SARS-CoV

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

COC1=C2C(NC(C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CNC3=O)C([H])=O)=O)=O)=C2)=CC=C1

Molecular Formula

C24H28N4O5

Molecular Weight

452.50

References & Citations

[1]Kumar V, et al. Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents. J Am Chem Soc. 2025 Jan 15;147 (2) :1631-1648.