VK13
VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) with a Ki value of 0.55 nM and SARS-CoV-2 3CLpro (3CL-PR) with a Ki value of 2.6 nM. VK13 exhibits anti-CoV-2 activity with an EC50 of 1.25 μM[1].
Product Specifications
UNSPSC
12352005
Target
Cathepsin; SARS-CoV
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
COC1=C2C(NC(C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CNC3=O)C([H])=O)=O)=O)=C2)=CC=C1
Molecular Formula
C24H28N4O5
Molecular Weight
452.50
References & Citations
[1]Kumar V, et al. Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents. J Am Chem Soc. 2025 Jan 15;147 (2) :1631-1648.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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