CYP51/Hsp90-IN-1

CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis[1].

Product Specifications

UNSPSC

12352005

Target

Cytochrome P450; Fungal; HSP

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

FC1=CC(F)=C(C=C1)C(CN2CCN(CC3=CC=C(N(C(C4=C(O)C=C(O)C(C5=CC=C(C)C=C5)=C4)=O)CC)C=C3)CC2)(CN6C=NC=N6)O

Molecular Formula

C38H40F2N6O4

Molecular Weight

682.76

References & Citations

[1]Zhang M, et al. Lanosterol 14α-Demethylase (CYP51) /Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis. J Med Chem. 2025 Jan 23;68 (2) :1668-1681.