G-quadruplex ligand 3

G-quadruplex ligand 3 (Compound 16) is a G-quadruplex ligand with anticancer effects that chelate iron. G-quadruplex ligand 3 stabilizes G-quadruplexes in human leukemia Jurkat cells. G-quadruplex ligand 3 localizes in the cell nucleus, serving as a fluorescent nuclear tracer for the labile iron pool[1].

Product Specifications

UNSPSC

12352005

Target

G-quadruplex

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C1C=C2N(C=C1O)C3=C(NC2=O)C=C(C(NCCCN(C)C)=O)C=C3

Molecular Formula

C18H20N4O4

Molecular Weight

356.38

References & Citations

[1]Piccolo M, et al. Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents. J Med Chem. 2025 Jan 23;68 (2) :1245-1259.