G-quadruplex ligand 3
G-quadruplex ligand 3 (Compound 16) is a G-quadruplex ligand with anticancer effects that chelate iron. G-quadruplex ligand 3 stabilizes G-quadruplexes in human leukemia Jurkat cells. G-quadruplex ligand 3 localizes in the cell nucleus, serving as a fluorescent nuclear tracer for the labile iron pool[1].
Product Specifications
UNSPSC
12352005
Target
G-quadruplex
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1C=C2N(C=C1O)C3=C(NC2=O)C=C(C(NCCCN(C)C)=O)C=C3
Molecular Formula
C18H20N4O4
Molecular Weight
356.38
References & Citations
[1]Piccolo M, et al. Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents. J Med Chem. 2025 Jan 23;68 (2) :1245-1259.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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