P162-0948
P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis[1].
Product Specifications
CAS Number
[1358201-44-1]
UNSPSC
12352005
Target
CDK; TGF-beta/Smad
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Infection
Smiles
FC1=CC=C(CNC(CC2=NN=C(C3=CC=C4C(C=CC=N4)=C3)O2)=O)C=C1
Molecular Formula
C20H15FN4O2
Molecular Weight
362.36
References & Citations
[1]Lin TE, et al. Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening. J Chem Inf Model. 2025 Jan 13;65 (1) :378-389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8
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