BET/Aurora kinase-IN-1
BET/Aurora kinase-IN-1 (Compound 38) is a dual BET/Aurora kinase inhibitor. BET/Aurora kinase-IN-1 shows antiproliferative activities on diverse cancer cell lines and favorable antitumor efficacy in renal cell cancer and colon cancer xenograft models with tumor growth inhibition (TGI) of 45.99% and 53.06%, respectively[1].
Product Specifications
CAS Number
[2674064-32-3]
UNSPSC
12352005
Target
Aurora Kinase
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CN(C1=O)C(C=CC(NC2=NC=C(C(C3=C(N(N=C3C4CC4)C)C)=N2)F)=C5)=C5N([C@@H]1C)C(C)C
Molecular Formula
C25H30FN7O
Molecular Weight
463.55
References & Citations
[1]Lyu K, et al. Structure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers. J Med Chem. 2025 Jan 23;68 (2) :1344-1364.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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