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RET-IN-29

RET-IN-29 (Compound 8W) is a selective RET kinase inhibitor. RET-IN-29 exhibits inhibitory potency against the BaF3 cells harboring CCDC6-RETV804M mutation with an IC50 value of 0.715 μM. RET-IN-29 is promising for research of non-small cell lung cancer (NSCLC) [1].

Product Specifications

UNSPSC

12352005

Target

RET

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CC1=C(N2C=CC(NC3=NC(N(C4CCC4)C(C=C5C)=O)=C5C=N3)=N2)C=CC=C1

Molecular Formula

C22H22N6O

Molecular Weight

386.45

References & Citations

[1]Shen J, et al. Structure-Based Design of 2-Aminopyrazolpyrimidopyridone Derivatives as New Rearranged During Transfection (RET) Kinase Inhibitors. Chem Biol Drug Des. 2025 Jan;105 (1) :e70039.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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