ERα degrader 12

ERα degrader 12 (Compound RA3) is an estrogen receptor α (ERα) degrader with antitumor properties. ERα degrader 12 induces pronounced tumor growth inhibition in a breast cancer xenograft mouse model[1].

Product Specifications

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC1=CC=C(C=C1)C2=C(C(C3=CC=C(OCCCNC([C@@]4(C5[C@@]67C([C@@H](CC5)C)CC[C@@](OO6)(O[C@H]7O4)C)C)=O)C=C3)=O)C8=CC=C(O)C=C8S2

Molecular Formula

C39H41NO9S

Molecular Weight

699.81

References & Citations

[1]Qing L, et al. Discovery of D-Ring-Contracted Artemisinin as a Potent Hydrophobic Tag for Targeted Protein Degradation. J Med Chem. 2025 Jan 23;68 (2) :1619-1631.