KPC-IN-1
KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2 (IC50=8.3 nM) . KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems. KPC causes significant bacterial resistance to carbapenem antibiotics[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
FC1=CC2=CC=CC(B(O)O)=C2N=C1C(O)=O
Molecular Formula
C10H7BFNO4
Molecular Weight
234.98
References & Citations
[1]Ma Z, et al. 2-Carboxyquinoline Boronic Acids as Highly Potent KPC Inhibitors. ChemMedChem. 2024 Dec 27:e202400901.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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