HNC-1664
HNC-1664 is the orally active inhibitor for RNA-dependent RNA polymerase (RdRP) . HNC-1664 exhibits broad-spectrum antiviral activity against coronavirus (SARS-CoV-2 wildtype and its mutants XBB.1.18, HK.3.1, BF.7.14, BA.1HCoV-229E, HCoV-OC43) and arenavirus. HNC-1664 exhibits anti-infectious activity in SARS-CoV-2 Delta infected mouse models[1].
Product Specifications
CAS Number
[2127358-36-3]
UNSPSC
12352005
Target
Arenavirus; DNA/RNA Synthesis; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
CC1=NC=NC2=C1C(I)=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](CO)O3
Molecular Formula
C12H13FIN3O3
Molecular Weight
393.15
References & Citations
[1]Jia X, et al., An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode. Nat Commun. 2024 Dec 30;15 (1) :10750.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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