α-Amylase-IN-11

α-Amylase-IN-11 (compound C5f) is an α-Amylase inhibitor (IC50=0.56 μM) that can reduce the sugar level in vivo. α-Amylase-IN-11 has a moderate inhibitory effect on α-glucosidase (α-glucosidase), with IC50=11.03 μM. α-Amylase-IN-11 can significantly reduce the glucose concentration in a mouse model and has the potential for use in diabetes research[1].

Product Specifications

UNSPSC

12352005

Target

Amylases

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

S=C1NN=C(CN2C3=C(C4=C2C=CC=C4)C=CC=C3)N1C5=CC=C(OC)C=C5

Molecular Formula

C22H18N4OS

Molecular Weight

386.47

References & Citations

[1]Çapan İ, et al. Next-Generation Carbazole-Linked 1,2,4-Triazole-Thione Derivatives: Strategic Design, Synthesis, Molecular Docking, and Evaluation of Antidiabetic Potential. ACS Omega. 2024 Dec 25;10 (1) :848-861.