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ALT-007

ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research[1].

Product Specifications

CAS Number

2035010-37-6

UNSPSC

12352005

Target

Acyltransferase; Ceramidase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

99.81

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1C(N(C(C)C)N=C2)=C2N(C(C3=CN=C(OC)C(OC)=C3)=O)CC1)C4=CC=CC=C4OC(F)(F)F

Molecular Formula

C25H26F3N5O5

Molecular Weight

533.50

References & Citations

[1]Poisson J, et al. Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia. ACS Pharmacol Transl Sci. 2024 Dec 29;8 (1) :203-215.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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