PD-L1/VISTA-IN-1
PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity[1].
Product Specifications
CAS Number
[2978623-09-3]
UNSPSC
12352005
Target
PD-1/PD-L1; VISTA
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)NC3=NC(OC)=CC(CN[C@H](C(O)=O)CO)=N3
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
References & Citations
[1]Sun C, et al. Novel PD-L1/VISTA Dual Inhibitor as Potential Immunotherapy Agents. J Med Chem. 2025 Jan 9;68 (1) :156-173.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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