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PDE7A-IN-1

PDE7A-IN-1 (Compound 26) is an orally active PDE7A inhibitor with an IC50 value of 3.7 nM. PDE7A-IN-1 significantly improves bone mineral density by inhibiting the sclerostin (sclerostin) and is suitable for the study of osteoporosis and related bone metabolic diseases[1].

Product Specifications

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C1N(CC)C(N[C@H]2CN(C(C3=NC=C(C4=CC=CC=C4)C=C3)=O)CC2)=NC(C5CC5)=C1Cl

Molecular Formula

C25H26ClN5O2

Molecular Weight

463.96

References & Citations

[1]Kondo K, et al. Discovery of a Phosphodiesterase 7A Inhibitor of High Isozyme Selectivity Exhibiting In Vivo Anti-Osteoporotic Effects. ACS Med Chem Lett. 2024 Dec 27;16 (1) :167-173.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE7

Frequently Asked Questions

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