DXR-IN-4
DXR-IN-4 (Compound 12a) is the inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) . DXR-IN-4 inhibits DXR in Plasmodium falciparum Pf DXR, Escherichia coli Ec DXR, and Mycobacterium tuberculosis Mt DXR with IC50s of 18, 4.9 and 89 nM, respectively. DXR-IN-4 exhibits antimalarial activity that inhibits P. falciparum strains 3D7 and Dd2 with IC50 of 11 μM and 12 μM[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
OP(C(C1=CC=CC(OCCCCCC)=C1)SCC(N(O)C)=O)(O)=O
Molecular Formula
C16H26NO6PS
Molecular Weight
391.42
References & Citations
[1]Knak T, et al., Expanding the Chemical Space of Reverse Fosmidomycin Analogs. ACS Med Chem Lett. 2024 Dec 23;16 (1) :136-143.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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