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DXR-IN-4

DXR-IN-4 (Compound 12a) is the inhibitor for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) . DXR-IN-4 inhibits DXR in Plasmodium falciparum Pf DXR, Escherichia coli Ec DXR, and Mycobacterium tuberculosis Mt DXR with IC50s of 18, 4.9 and 89 nM, respectively. DXR-IN-4 exhibits antimalarial activity that inhibits P. falciparum strains 3D7 and Dd2 with IC50 of 11 μM and 12 μM[1].

Product Specifications

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

OP(C(C1=CC=CC(OCCCCCC)=C1)SCC(N(O)C)=O)(O)=O

Molecular Formula

C16H26NO6PS

Molecular Weight

391.42

References & Citations

[1]Knak T, et al., Expanding the Chemical Space of Reverse Fosmidomycin Analogs. ACS Med Chem Lett. 2024 Dec 23;16 (1) :136-143.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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