MDI-114215
MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research[1].
Product Specifications
UNSPSC
12352005
Target
LIM Kinase (LIMK)
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CC1CC1)CC2=CC=C(NCCO)C=C2)C3=CC=C(S(=O)(NC4=CC=CC=C4)=O)C=C3
Molecular Formula
C26H29N3O4S
Molecular Weight
479.59
References & Citations
[1]Baldwin AG, et al. Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome. J Med Chem. 2025 Jan 9;68 (1) :719-752.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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