MDI-114215
MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research[1].
Product Specifications
UNSPSC
12352005
Target
LIM Kinase (LIMK)
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.29
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CC1CC1)CC2=CC=C(NCCO)C=C2)C3=CC=C(S(=O)(NC4=CC=CC=C4)=O)C=C3
Molecular Formula
C26H29N3O4S
Molecular Weight
479.59
References & Citations
[1]Baldwin AG, et al. Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome. J Med Chem. 2025 Jan 9;68 (1) :719-752.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![PE/Cyanine7 Anti-Human CD95/Fas Antibody[DX2]](https://cdn.genprice.uk/products/763/68dd14ad061270361e7d3396/imageurl/e-ab-f1168h.webp)
E-AB-F1168H-01 20 Tests
PE/Cyanine7 Anti-Human CD95/Fas Antibody[DX2]
Sign In for Pricing
View Details E-AB-F1168H-02 100 Tests
PE/Cyanine7 Anti-Human CD95/Fas Antibody[DX2]
Sign In for Pricing
View Details E-AB-F1168H-03 2x 100 Tests
PE/Cyanine7 Anti-Human CD95/Fas Antibody[DX2]
Sign In for Pricing
View Details ![ICAM1 Recombinant Rabbit Monoclonal Antibody [PSH09-31]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea81185/imageurl/ha723089.webp)
HA723089 100 µL
ICAM1 Recombinant Rabbit Monoclonal Antibody [PSH09-31]
Sign In for Pricing
View Details 
