DSM1465

DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].

Product Specifications

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; Parasite

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C1C2=NN(C)C([C@](O)(C3=CC(Cl)=C(C(F)(F)F)N=C3)C(F)(F)F)=C2N=CN1C4CC4

Molecular Formula

C17H12ClF6N5O2

Molecular Weight

467.75

References & Citations

[1]Nie Z, et al. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 Jan 9;68 (1) :590-637.