DSM1465
DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Parasite
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C1C2=NN(C)C([C@](O)(C3=CC(Cl)=C(C(F)(F)F)N=C3)C(F)(F)F)=C2N=CN1C4CC4
Molecular Formula
C17H12ClF6N5O2
Molecular Weight
467.75
References & Citations
[1]Nie Z, et al. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 Jan 9;68 (1) :590-637.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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