DSM1465
DSM1465 (Compound 82) is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM. DSM1465 shows potent in vivo activity in the humanized P. falciparum mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Parasite
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C1C2=NN(C)C([C@](O)(C3=CC(Cl)=C(C(F)(F)F)N=C3)C(F)(F)F)=C2N=CN1C4CC4
Molecular Formula
C17H12ClF6N5O2
Molecular Weight
467.75
References & Citations
[1]Nie Z, et al. Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention. J Med Chem. 2025 Jan 9;68 (1) :590-637.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC682848-100 1x 100 µL
Fibronectin (Fn-3), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940181-100 1x 100 µL
CD59 (heavy chain of Protectin) (BRA-10G), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941009-500 1x 500 µL
CD66 (CEA) (C66/1009), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401541-100 1x 100 µL
Calnexin (Endoplasmic Reticulum Marker) (CANX/1541), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 