Tubulin polymerization-IN-77

Tubulin polymerization-IN-77 (Compound 15c) is a tubulin polymerization inhibitor that exerts anti-glioblastoma activity by inhibiting tubulin polymerization. Tubulin polymerization-IN-77 demonstrates significant blood-brain barrier permeability, effectively inducing G2/M phase arrest and triggering apoptosis in GBM cells, while also significantly inhibiting tumor cell migration[1].

Product Specifications

CAS Number

[3023350-32-2]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

COC1=C(OCO2)C2=C(Br)C3=C1[C@@]([C@]4([H])C5=CC=C(OC)C(OC)=C5C(O4)=O)([H])N(CC3)C(F)(F)F

Molecular Formula

C22H19BrF3NO7

Molecular Weight

546.29

References & Citations

[1]Cui G, et al. Discovery of N-Trifluoromethylated Noscapines as Novel and Potent Agents for the Treatment of Glioblastoma. J Med Chem. 2025 Jan 9;68 (1) :247-260.