AXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1 (compound 11b) is an AXL/triple angiokinase inhibitor, IC50=3.75 nM (AXL expression) . AXL/Angiokinase-IN-1 inhibits epithelial-mesenchymal transition (EMT) in Bxpc-3, blocking lung cancer cell metastasis. AXL/Angiokinase-IN-1 also inhibits vascular and fibroblast functions, promoting apoptosis (apoptosis) in cancer cells and fibroblasts. AXL/Angiokinase-IN-1 features low toxicity and good metabolic stability[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FGFR; PDGFR; VEGFR
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1NC2=CC(Cl)=CC=C2/C1=C(C3=CC=CC=C3)/NC4=CC=C(C=C4)N(C)C(C(C)N5CCN(CC5)CC)=O
Molecular Formula
C31H34ClN5O2
Molecular Weight
544.09
References & Citations
[1]Yao H, et al. The Discovery of a Novel AXL/Triple Angiokinase Inhibitor Based on 6-Chloro-Substituted Indolinone and Side Chain Methyl Substitution Inhibiting Pancreatic Cancer Growth and Metastasis. J Med Chem. 2025 Jan 9;68 (1) :465-490.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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