AXL/Angiokinase-IN-1

AXL/Angiokinase-IN-1 (compound 11b) is an AXL/triple angiokinase inhibitor, IC50=3.75 nM (AXL expression) . AXL/Angiokinase-IN-1 inhibits epithelial-mesenchymal transition (EMT) in Bxpc-3, blocking lung cancer cell metastasis. AXL/Angiokinase-IN-1 also inhibits vascular and fibroblast functions, promoting apoptosis (apoptosis) in cancer cells and fibroblasts. AXL/Angiokinase-IN-1 features low toxicity and good metabolic stability[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; FGFR; PDGFR; VEGFR

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1NC2=CC(Cl)=CC=C2/C1=C(C3=CC=CC=C3)/NC4=CC=C(C=C4)N(C)C(C(C)N5CCN(CC5)CC)=O

Molecular Formula

C31H34ClN5O2

Molecular Weight

544.09

References & Citations

[1]Yao H, et al. The Discovery of a Novel AXL/Triple Angiokinase Inhibitor Based on 6-Chloro-Substituted Indolinone and Side Chain Methyl Substitution Inhibiting Pancreatic Cancer Growth and Metastasis. J Med Chem. 2025 Jan 9;68 (1) :465-490.