Hypoxia inducer-1

Hypoxia inducer-1 (Compound N6) is an orally active hypoxia activated nitric oxide (NO) donor compound. Hypoxia inducer-1 exhibits highly selective NO release under hypoxic conditions and inhibits hypoxia-induced apoptosis, necrosis, and the increase in ROS levels. Hypoxia inducer-1 regulates vascular dilation and has a protective effect in a mouse model of myocardial hypoxia injury. Hypoxia inducer-1 can be used in the research of coronary heart disease[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cardiovascular Disease

Smiles

CN(C1=CC=C(OCC2=CC(F)=C(C=C2)[N+]([O-])=O)C=C1)N=O

Molecular Formula

C14H12FN3O4

Molecular Weight

305.26

References & Citations

[1]Yang W, et al. Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury. J Med Chem. 2025 Jan 9;68 (1) :491-505.