α5-GABAA receptor modulator 1
α5-GABAA receptor modulator 1 (Compound A-4) is a silencing allosteric modulator (SAM) specifically targeting the a5 subunit of the GABAA receptor, suitable for research into central nervous system (CNS) disorders[1].
Product Specifications
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=C(C(C2=CC=C(C=C2)F)=NO1)COC3=CC4=C(C(N(CC4)CCO)=O)C=N3
Molecular Formula
C21H20FN3O4
Molecular Weight
397.40
References & Citations
[1]Krámos B, et al. Ligand Binding and Functional Effect of Novel Bicyclic α5 GABAA Receptor Negative Allosteric Modulators. J Chem Inf Model. 2025 Jan 13;65 (1) :402-416.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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