TLR7/8 agonist 12

TLR7/8 agonist 12 (compound 9) is an hTLR7/8 agonist, with EC50 values of 11 nM (hTLR7) and 150 nM (hTLR8), respectively. TLR7/8 agonist 12 has the potential for immunomodulation[1].

Product Specifications

CAS Number

[3080931-00-3]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OCC[C@H](CCC)NC1=NC(N)=NC2=C1N(CC3=C(OC)C=CC(CN[C@@H]4COCC4)=C3)C5=C2C=CC=C5

Molecular Formula

C29H38N6O3

Molecular Weight

518.65

References & Citations

[1]Poudel YB, et al. Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach. ACS Med Chem Lett. 2024 Dec 19;16 (1) :80-88.