FLT3 Ligand-Linker Conjugate 1

FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the FLT3 ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062) . PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases[1].

Product Specifications

CAS Number

[2769753-49-1]

UNSPSC

12352005

Target

FLT3; Target Protein Ligand-Linker Conjugates

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CS(NC1=CC=CC(C2=CSC3=CN=C(N=C23)NC4=CC=C(N5CCN(CC5)CCCCCC(O)=O)C=C4)=C1)(=O)=O

Molecular Formula

C29H34N6O4S2

Molecular Weight

594.75

References & Citations

[1]Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.