ATX-IN-1
ATX-IN-1 (compound 35) is an inhibitor of ATX (IC50=0.7 nM) with anti-inflammatory activity. ATX-IN-1 can inhibit TGF-β/Smad pathway and reduce collagen deposition to alleviate Bleomycin -induced fibrosis in mice. ATX-IN-1 has good oral bioavailability (F=69.5%) and particle stability[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1N(CCC2=C1N(C3=CN(COC)N=C3)N=C2C(NC4=CC=CC=C4C(O)=O)=O)C5=CC=CC=C5
Molecular Formula
C25H22N6O5
Molecular Weight
486.48
References & Citations
[1]Ma D, et al. Discovery of Novel 4,5,6,7-Tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one Derivatives as Orally Efficacious ATX Allosteric Inhibitors for the Treatment of Pulmonary Fibrosis. J Med Chem. 2025 Jan 9;68 (1) :792-818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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