M3686
M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model[1].
Product Specifications
CAS Number
2738550-24-6
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
O[C@@H]1CN(C(C2=CC3=C(N(C4=CC=C(C(F)(F)F)C=C4)C5=NN(C)N=C53)C=C2)=O)CC1
Molecular Formula
C21H18F3N5O2
Molecular Weight
429.40
References & Citations
[1]Heinrich T, et al. MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686. J Med Chem. 2024 Dec 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
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