(-) -Mcl-1 inhibitor 21
(-) -Mcl-1 inhibitor 21 (Example 1-38) is a Mcl-1 inhibitor with an IC50 of 7.51 μM. (-) -Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research[1].
Product Specifications
CAS Number
[2157421-24-2]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(C1=C(CCCOC2=CC=CC3=C2C=CC=C3)C4=C5N1CCCCOCC6=NN(C)C(C)=C6C5=CC=C4)O
Molecular Formula
C32H33N3O4
Molecular Weight
523.62
References & Citations
[1]Sarah W, et al. Macrocyclic indole derivatives. WO2017198341A1. 2017-11-23
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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