(+) -Mcl-1 inhibitor 21

(+) -Mcl-1 inhibitor 21 (Example 1-37) is a Mcl-1 inhibitor with an IC50 of 172 nM. (+) -Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research[1].

Product Specifications

CAS Number

[2157421-23-1]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

O=C(C1=C(CCCOC2=CC=CC3=C2C=CC=C3)C4=C5N1CCCCOCC6=NN(C)C(C)=C6C5=CC=C4)O

Molecular Formula

C32H33N3O4

Molecular Weight

523.62

References & Citations

[1]Sarah W, et al. Macrocyclic indole derivatives. WO2017198341A1. 2017-11-23

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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