KEAP1-NRF2 PPI-IN-1
KEAP1-NRF2 PPI-IN-1 (compound 23) is an inhibitor targeting the KEAP1-NRF2 interaction. KEAP1-NRF2 PPI-IN-1 has IC50 values of 136 nM and 62 nM in the DNA damage assays of human TK6 and insect SF9 cell lines, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Keap1-Nrf2
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=CC=CC=C1S(C2=C(N3CCN(C)C([C@H]3C)=O)SC(S(=O)(CC)=O)=N2)(=O)=O
Molecular Formula
C17H20ClN3O5S3
Molecular Weight
478.01
References & Citations
[1]Fejes I, et al. Covalent Inhibitors of KEAP1 with Exquisite Selectivity. J Med Chem. 2024 Dec 12;67 (23) :21208-21222.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1412758-01 0.02 mg (E-Coli)
Recombinant Geobacillus kaustophilus Imidazole glycerol phosphate synthase subunit HisH (hisH)
Ask
View Details 
MBS1412758-02 0.1 mg (E-Coli)
Recombinant Geobacillus kaustophilus Imidazole glycerol phosphate synthase subunit HisH (hisH)
Ask
View Details 
MBS1412758-03 0.02 mg (Yeast)
Recombinant Geobacillus kaustophilus Imidazole glycerol phosphate synthase subunit HisH (hisH)
Ask
View Details MBS1412758-04 0.1 mg (Yeast)
Recombinant Geobacillus kaustophilus Imidazole glycerol phosphate synthase subunit HisH (hisH)
Ask
View Details MBS1412758-05 0.02 mg (Baculovirus)
Recombinant Geobacillus kaustophilus Imidazole glycerol phosphate synthase subunit HisH (hisH)
Ask
View Details MBS1412758-06 0.02 mg (Mammalian-Cell)
Recombinant Geobacillus kaustophilus Imidazole glycerol phosphate synthase subunit HisH (hisH)
Ask
View Details