Antibacterial agent 258

Antibacterial agent 258 (Compound 11e) is an antibacterial agent, that destory the bacteria cell membrane, and inhibits various gram-positive bacteria (MIC for Staphylococcus aureus is 1-2 μg/mL) . Antibacterial agent 258 exhibits low hemolytic activity and low cytotoxicity. Antibacterial agent 258 exhibits anti-infectious efficacy in mouse models[1].

Product Specifications

CAS Number

[3054254-13-3]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC(C3=C4)=CNC3=CC=C4CNCC)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6([C@](C[C@@H](CC6)O)([H])CC5)C

Molecular Formula

C33H50N2O

Molecular Weight

490.76

References & Citations

[1]Huo H, et al., Design, synthesis, and biological evaluation of steroidal indole derivatives as membrane-targeting antibacterial candidates. Eur J Med Chem. 2025 Feb 5;283:117156.