HAChE/hBuChE-IN-1
HAChE/hBuChE-IN-1 (compound C2) is a dual inhibitor of cholinesterase with IC50 values of 514 nM and 358 nM for hAChE and hBuChE respectively. hAChE/hBuChE-IN-1 has oral activity and improves cognition and spatial memory[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CN1CC2=CC=C(OC)C(O[C@@]3([H])C[C@@H](OCC4=NC=C(CC5=CC=CC=C5F)C=C4)C=C6)=C2[C@@]36CC1
Molecular Formula
C30H31FN2O3
Molecular Weight
486.58
References & Citations
[1]Mengzhen Li, et al. Design, synthesis and biological evaluation of galantamine analogues for cognitive improvement in Alzheimer's disease. Eur J Med Chem. 2025 Feb 15:284:117198.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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