FGFR4-IN-22

FGFR4-IN-22 (compound 10f) is a potent inhibitor of FGFR4, with the IC50 of 5.4 nM. FGFR4-IN-22 serve as a potential lead compound targeting FGFR4 for anti-HCC agent development[1].

Product Specifications

CAS Number

[2922812-74-4]

UNSPSC

12352005

Target

FGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC1=CC=CC(C)=C1NC2=NC=C(C=N2)C#CC3=CC=CC(C(NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4)=O)=C3)C=C

Molecular Formula

C36H34F3N7O2

Molecular Weight

653.70

References & Citations

[1]Lei Han, et al. Design, synthesis, and biological evaluation of Ponatinib-based N-Phenylpyrimidine-2-amine derivatives as novel fibroblast growth factor receptor 4 (FGFR4) selective inhibitors. Eur J Med Chem. 2025 Feb 15:284:117206.