Antibacterial agent 119

Antibacterial agent 119 (Compound 21 g) is an antibacterial candidate against Methicillin (HY-121544) -resistant Staphylococcus aureus (MICs less than 1 μg/mL against tested strains) . Antibacterial agent 119 induces ROS production. Antibacterial agent 119 also acts on the bacterial cell membrane to cause membrane breakage. Antibacterial agent 119 exhibits potent antibacterial activity with low cytotoxicity, rapid bactericidal ability, and good in vivo antibacterial activity[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

C[C@@]12[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](CCC5=[N+](CC6=CC=C(Cl)C=C6)C=CC7=C5NC8=C7C=C(OC)C=C8)C)([H])C[C@H](O)CC1.[Br-]

Molecular Formula

C42H54BrClN2O4

Molecular Weight

766.25

References & Citations

[1]Huo H, et al. Novel steroidal β-carboline derivatives as promising antibacterial candidates against methicillin-resistant Staphylococcus aureus. Eur J Med Chem. 2025 Feb 5;283:117187.