BRD4 Inhibitor-38
BRD4 Inhibitor-38 (Compound 25) is an orally active inhibitor of BRD4 with IC50 values of 3.64 μM and 0.12 μM against BRD4 BD1 and BRD4 BD2, respectively. BRD4 Inhibitor-38 also exhibits anti-inflammatory activity, with an IC50 value of 1.98 μM for inhibiting nitric oxide (NO) production[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC1=C2C(N=C(/C=C/C3=CC=C(OC)C=C3)NC2=O)=CC(OC)=C1
Molecular Formula
C19H18N2O4
Molecular Weight
338.36
References & Citations
[1]Chen S, et al. Marine natural product-inspired discovery of novel BRD4 inhibitors with anti-inflammatory activity[J]. European Journal of Medicinal Chemistry, 2024: 117193.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
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