XPO1-ligand-1
XPO1-ligand-1 is a target protein ligand for XPO1 and can be used to synthesize PROTAC PROTAC XPO1 degrader-1 (HY-170669) [1].
Product Specifications
CAS Number
[1076236-11-7]
UNSPSC
12352005
Target
CRM1; Ligands for Target Protein for PROTAC
Related Pathways
Membrane Transporter/Ion Channel; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=C(C(F)(F)F)C=CC(NN2C(C(C)=C(CCC(O)=O)C2=O)=O)=N1
Molecular Formula
C14H11ClF3N3O4
Molecular Weight
377.70
References & Citations
[1]Guangyong Chen, et al. Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia. Eur J Med Chem. 2025 Feb 5:283:117182.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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