E3 ligase Ligand 49

E3 ligase Ligand 49 serves as the E3 ubiquitin ligase ligand for PROTAC XPO1 degrader-1 (HY-170669) . E3 ligase Ligand 49 can be utilized for the synthesis of PROTACs[1].

Product Specifications

CAS Number

[1911013-66-5]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=C(C(NC2C(NC(CC2)=O)=O)=O)C=CC=C1N

Molecular Formula

C13H15N3O4

Molecular Weight

277.28

References & Citations

[1]Guangyong Chen, et al. Discovery of novel XPO1 PROTAC degraders for the treatment of acute myeloid leukemia. Eur J Med Chem. 2025 Feb 5:283:117182.